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The urinary measurement of nicotine metabolites has several applications, including public tobacco exposure monitoring, nicotine replacement therapy evaluation, drug therapy assessment, forensic toxicology analysis, and life or health insurance application

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Prenatal exposure is particularly concerning, as arsenic can cross the placental barrier and affect fetal brain development, increasing the risk of neurodevelopmental disorders such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD)